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Related Experiment Videos

Are small changes in serum creatinine an important risk factor?

Melanie L Praught1, Michael G Shlipak

  • 1General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

Current Opinion in Nephrology and Hypertension
|April 12, 2005
PubMed
Summary

Acute elevations in serum creatinine, a marker of worsening renal function, linearly increase mortality risk in cardiac surgery and heart failure patients. Further research is needed to identify interventions for in-hospital renal function decline.

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Area of Science:

  • Nephrology
  • Cardiology
  • Critical Care Medicine

Background:

  • Serum creatinine levels are linked to cardiovascular disease and mortality.
  • Recent research explores if minor creatinine increases (worsening renal function) independently predict adverse outcomes.

Purpose of the Study:

  • To review recent literature on worsening renal function as an independent risk factor for adverse outcomes.

Main Methods:

  • Review of recent studies evaluating worsening renal function in cardiac surgery, heart failure, and coronary artery disease patients.
  • Analysis of associations between creatinine changes and mortality risk.

Main Results:

  • Small creatinine increases post-cardiac surgery strongly correlate with mortality.

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  • Worsening renal function predicts mortality in hospitalized heart failure patients, independent of baseline creatinine.
  • A linear association exists between creatinine rise magnitude and mortality risk in these populations.

    • Conclusions:

    • Acute serum creatinine elevations are linearly associated with increased adverse outcomes in hospitalized cardiac surgery and heart failure patients.
    • Interventions to prevent and treat in-hospital worsening renal function are needed to mitigate adverse outcomes.