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Related Experiment Videos

Adrenocortical function in patients investigated for active tuberculosis.

E L York1, D A Enarson, E J Nobert

  • 1Division of Pulmonary Medicine and Tuberculosis Services, Alberta Health, University of Alberta, Edmonton, Canada.

Chest
|May 1, 1992
PubMed
Summary

This study investigated adrenal function in patients with active pulmonary tuberculosis. Results indicate no significant decrease in serum cortisol levels, suggesting active tuberculosis does not impair adrenocortical function.

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Pulmonology

Background:

  • Previous reports suggest a link between active pulmonary tuberculosis and adrenal insufficiency.
  • Adrenocortical function requires further investigation in tuberculosis patients.

Purpose of the Study:

  • To assess serum cortisol levels and adrenocortical function in patients with active pulmonary tuberculosis.
  • To determine if active pulmonary tuberculosis is associated with decreased adrenocortical function.

Main Methods:

  • Serum cortisol levels (morning and afternoon) were measured in 37 patients upon hospital admission before treatment.
  • Patients were categorized into three groups: active pulmonary tuberculosis, other mycobacterial disease, and suspected tuberculosis.
  • Diurnal change in serum cortisol was calculated and analyzed in relation to disease extent.

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Main Results:

  • No significant difference in morning or afternoon serum cortisol levels was observed among the three patient groups.
  • A significantly decreased diurnal change in cortisol levels was noted in patients with extensive disease compared to limited disease.
  • No association was found between cortisol levels and age, gender, or race.

Conclusions:

  • Active pulmonary tuberculosis in this patient cohort does not appear to be associated with decreased adrenocortical function.
  • While extensive disease showed a reduced diurnal cortisol change, overall adrenocortical function remained comparable to control groups.