A novel formal total synthesis of cephalotaxine
1State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liwd@lzu.edu.cn
The Journal of Organic Chemistry
|April 13, 2005
Abstract:
A formal total synthesis of cephalotaxine (CET), the parent structure of antileukemia Cephalotaxus alkaloids, was achieved through a novel synthesis of the pentacyclic amino enone 4 by a rapid annulation of readily available beta-(3,4-methylenedioxy)phenethylamine (2), delta-valerolactone, and bromoacetone.

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