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MORE--MOexipril and REgression of left ventricle hypertrophy in combination therapy A multicentric open label

J Spinar1, J Vítovec,

  • 1Department of Internal Medicine II, St Ann's Teaching Hospital, Brno, Czech Republic. jspinar@med.muni.cz

International Journal of Cardiology
|April 13, 2005
PubMed

Insights

Adding the ACE inhibitor moexipril to hypertension treatment significantly reduced blood pressure and left ventricle mass. The combination of moexipril with a thiazide diuretic proved most effective, with minimal adverse effects observed.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Management

Background:

  • Poorly controlled hypertension poses significant cardiovascular risks.
  • Combination therapy is often necessary for effective blood pressure management.
  • Angiotensin-Converting Enzyme (ACE) inhibitors are a cornerstone in hypertension treatment.

Purpose of the Study:

  • To assess the efficacy of adding the ACE inhibitor moexipril to existing antihypertensive regimens.
  • To evaluate the impact of moexipril on blood pressure and cardiac structure in patients with resistant hypertension.
  • To compare the effectiveness of moexipril in different combination therapy settings.

Main Methods:

  • A single-blind, multicenter study involving 420 patients with inadequately controlled hypertension.
  • Moexipril was added to existing monotherapy or dual-drug regimens lacking ACE inhibitors or Angiotensin II Receptor antagonists.
  • Echocardiography was performed at baseline and after 6 months to assess cardiac remodeling, alongside regular blood pressure monitoring.

Main Results:

  • Significant reductions in systolic and diastolic blood pressure (p<0.0001) and heart rate (p<0.0001) were observed.
  • Left ventricle mass (p<0.0001), left atrium size (p<0.0001), and E/A ratio (p<0.0005) showed significant improvements.
  • Moexipril addition to diuretics demonstrated a statistically greater effect on reducing left ventricle mass compared to calcium channel blockers or beta-blockers.

Conclusions:

  • Adding moexipril to combination therapy effectively reduces blood pressure and left ventricle mass, comparable to monotherapy trials.
  • The combination of an ACE inhibitor with a thiazide diuretic appears to be the most effective regimen.
  • Moexipril was well-tolerated, with a low incidence of adverse events, and improved lipid profiles.
Abstract

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