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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Evaluation of isoprinosine in experimental human rhinovirus infection

D M Pachuta, Y Togo, R B Hornick

    Antimicrobial Agents and Chemotherapy
    |April 1, 1974
    PubMed

    Insights

    Isoprinosine did not significantly prevent or reduce the severity of rhinovirus colds in volunteers. While some trends favored the drug, its prophylactic effect was not convincingly apparent in this study.

    Area of Science:

    • Virology
    • Immunology
    • Pharmacology

    Background:

    • The common cold is frequently caused by rhinoviruses.
    • Effective prophylactic treatments for rhinovirus infections are limited.

    Purpose of the Study:

    • To evaluate the prophylactic efficacy of isoprinosine against rhinovirus challenge.
    • To assess the impact of isoprinosine on cold symptom occurrence and severity.

    Main Methods:

    • A double-blind, placebo-controlled study involving volunteers challenged with rhinovirus 44 and 32.
    • Volunteers received either oral isoprinosine (6 g/day) or placebo for 2 days before and 7 days after intranasal viral challenge.
    • Measurements included cold occurrence, severity, antibody titers, and viral isolations.

    Main Results:

    • The occurrence and severity of colds were numerically greater in the placebo groups for both rhinovirus trials.
    • Higher antibody titers and more rhinovirus 32 isolations were observed in the isoprinosine group.
    • Statistical significance was not achieved for any of the observed differences between the drug and placebo groups.

    Conclusions:

    • Isoprinosine treatment showed a potential to suppress cold symptoms, but the effect was not statistically significant.
    • Further research may be needed to clarify the prophylactic role of isoprinosine in rhinovirus infections.

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