Interaction between morin and sodium dodecyl sulfate (SDS) micelles

Area of Science:

• Physical Chemistry
• Supramolecular Chemistry
• Spectroscopy

Background:

• Morin, a natural flavonoid, exhibits interesting photophysical properties.
• Sodium dodecyl sulfate (SDS) micelles provide a versatile microenvironment for studying molecular interactions.
• Understanding molecular behavior within micelles is crucial for drug delivery and material science applications.

Purpose of the Study:

• To investigate the photophysical and electrochemical properties of morin within SDS micelles.
• To elucidate the binding mechanism and microenvironment of morin in different SDS micelle structures.
• To determine the thermodynamic parameters governing morin-SDS micelle interactions.

Main Methods:

• Electronic absorption and fluorescence emission spectroscopy.
• Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy.
• Cyclic voltammetry and ab initio quantum chemical calculations.

Main Results:

• Morin's phenyl group embeds into SDS micelles, increasing molecular planarity and pi-conjugation.
• Hydroxyl group interaction with the hydrophobic micelle core shifts oxidation potential and decreases peak current.
• Morin exhibits higher binding constants and distribution coefficients in spherical SDS micelles compared to rod-like micelles.

Conclusions:

• Morin's solubilization in SDS micelles is driven by hydrophobic forces.
• The binding process is spontaneous (ΔG < 0) and exothermic (ΔH < 0).
• SDS micelle microstructure significantly influences morin's binding affinity and properties.