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Updated: Aug 18, 2026

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

[Fungal sepsis--therapeutical strategy]

K H Staubach1

  • 1Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.

Mycoses
|April 14, 2005
PubMed

Insights

Fungal infections and sepsis are rising, often due to antibiotic use altering microbial balance. Early interventions, including restricted antibiotic use and comprehensive supportive care, can improve outcomes for septic patients.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Mycology

Context:

  • Rising incidence of fungal infections and fungal sepsis globally.
  • Alterations in local microbial flora due to broad-spectrum antibiotic therapy promote Candida species overgrowth.
  • Increasing challenges in managing invasive fungal infections and sepsis.

Purpose:

  • To review current understanding of fungal infection and sepsis.
  • To discuss prophylactic strategies against fungal infections.
  • To outline effective treatment modalities for septic syndrome.

Summary:

  • Broad-spectrum antibiotics disrupt normal flora, leading to Candida overgrowth and increased fungal infections/sepsis.
  • Prophylaxis involves judicious antibiotic use to prevent fungal overgrowth.
  • Treatment of septic syndrome requires a multi-faceted approach including cardiovascular support, hydrocortisone, insulin therapy, activated Protein C, and source control.

Impact:

  • Highlights the need for strategic antibiotic stewardship to mitigate fungal infections.
  • Emphasizes the importance of early, goal-directed therapies in improving septic patient outcomes.
  • Provides a comprehensive overview of management strategies for fungal sepsis.

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