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Related Experiment Videos

Human angular vestibulo-ocular reflex initiation: relationship to Listing's law.

Benjamin T Crane1, Jun-Ru Tian, Joseph L Demer

  • 1Department of Surgery, University of California, Los Angeles, CA 90032, USA.

Annals of the New York Academy of Sciences
|April 14, 2005
PubMed
Summary

The vestibulo-ocular reflex (VOR) axis deviates from head rotation, influenced by eye position. This "quarter-angle" behavior, observed early in VOR, likely results from orbital mechanics interacting with neural commands.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Biomechanics

Background:

  • The vestibulo-ocular reflex (VOR) stabilizes gaze during head movements.
  • Listing's Law (LL) describes eye rotation constraints during visual tracking.
  • Recent findings suggest VOR axis deviates from head rotation, influenced by eye position.

Purpose of the Study:

  • To investigate the variability and timing of VOR axis changes.
  • To test the plausibility of dynamic neural control models for VOR axis.
  • To understand the influence of eye position on VOR axis orientation.

Main Methods:

  • Defined binocular Listing's Planes (LPs) in eight human subjects.
  • Evoked VOR using transient yaw rotation in darkness.
  • Measured eye and head positions in LP coordinates, varying target fixation (eye level, up, down).

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Main Results:

  • VOR axis tilted approximately 28% with changes in vertical eye position, showing significant intrasubject variation (14%-41%).
  • This "quarter-angle" behavior was present from the earliest detectable VOR.
  • Eye position generally followed head position but departed LP when the head tilted out of LP.

Conclusions:

  • The observed VOR axis dependence on eye position is rapid and highly variable between individuals.
  • This behavior is likely influenced by orbital mechanics interacting with VOR neural commands.
  • The VOR shows a small deviation from Listing's Law in the position domain.