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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
[Autoimmunity in pathogenesis of chronic obstructive pulmonary disease]
Daiva Urboniene1, Raimundas Sakalauskas, Brigita Sitkauskiene
1Department of Pulmonology and Immunology, Institute for Biomedical Research, Kaunas University of Medicine, 50009 Kaunas, Lithuania. daivaurboniene@one.lt
Abstract:
For years, smoking induced inflammatory reaction, comprised mainly of neutrophils and macrophages, has been accepted to be the major component in pathogenesis of chronic obstructive pulmonary disease. New developments in molecular and cell biology have provided scientists with new knowledge and understanding of inflammatory processes in lung. Recent reports have underlined the role of autoimmunity and T lymphocytes as a potential important factor, which takes place in the pathogenesis of chronic obstructive pulmonary disease. This article reviews potential mechanism of T cell mediated immune response in chronic obstructive pulmonary disease.
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