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Updated: Aug 18, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
Published on: May 24, 2024
Development of new calcium receptors based on oxazolidin-2-ones containing pseudopeptides
Gianluigi Luppi1, Andrea Garelli, Luca Prodi
1Dipartimento di Chimica G. Ciamician - Alma Mater Studiorum, Universita di Bologna, Italy.
Abstract:
With the aim of designing a new calcium receptor, the synthesis and the conformational analysis of a small library of dipeptides having the general formula Ac-Oxx-L-Xaa-OBn [Oxx = L-Oxd, (4S,5R)-4-methyl-5-carboxyoxazolidin-2-one; D-Oxd, (4R,5S)-4-methyl-5-carboxyoxazolidin-2-one; or D-Oxac (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid] is reported. Ac-L-Oxd-L-Ala-OBn was identified as the most promising compound by MS-ESI analysis and this outcome was confirmed by photoluminescence spectroscopy.
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