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Axillary recurrence after sentinel node biopsy.

Jacqueline Sara Jeruss1, David J Winchester, Stephen F Sener

  • 1Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois 60611, USA.

Annals of Surgical Oncology
|April 14, 2005
PubMed
Summary
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Axillary recurrence after sentinel node biopsy (SNB) for breast cancer is rare, even with positive nodes. This study confirms SNB accurately assesses nodal disease and provides regional control.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Breast Cancer Research

Background:

  • Sentinel node biopsy (SNB) is the standard for breast cancer surgical staging.
  • SNB accurately assesses axillary nodal disease.
  • Hypothesis: Axillary recurrence post-SNB is rare, and SNB offers regional control for microscopic nodal involvement.

Purpose of the Study:

  • To evaluate the incidence of axillary recurrence after sentinel node biopsy (SNB).
  • To determine if SNB provides adequate regional control in breast cancer patients with nodal involvement.

Main Methods:

  • Prospective study of 864 breast cancer patients undergoing SNB from 1996-2003.
  • Median follow-up of 27.4 months.
  • Analysis of axillary recurrence rates based on sentinel node status and treatment (completion axillary dissection vs. observation).

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Main Results:

  • Only 2 of 864 patients (0.23%) experienced axillary recurrence.
  • One recurrence occurred in a sentinel node-negative patient who had undergone completion axillary dissection.
  • No axillary recurrences were observed in sentinel node-positive patients managed with observation alone.

Conclusions:

  • Axillary recurrence after SNB is exceptionally rare, regardless of nodal status.
  • SNB is an accurate method for staging axillary disease in breast cancer.
  • SNB provides effective regional control for patients with node-positive disease.