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Updated: Aug 18, 2026

Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
Published on: June 9, 2023
Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold
Janina Kneipp1, Harald Kneipp, William L Rice
1Wellman Center for Photomedicine, Harvard University, Medical School, Boston, Massachusetts 02139, USA. jkneipp@janina-kneipp.de
Abstract:
We report surface-enhanced Raman scattering (SERS) studies on indocyanine green (ICG) on colloidal silver and gold and demonstrate a novel optical probe for applications in living cells. In addition to its own detection by the characteristic ICG SERS signatures, the ICG gold nanoprobe delivers spatially localized chemical information from its biological environment by employing SERS in the local optical fields of the gold nanoparticles. The probe offers the potential to increase the spectral specificity and selectivity of current chemical characterization approaches of living cells and biomaterials based on vibrational information.
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