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Perspectives on the origins of multiple myeloma and plasmacytomas in mice
1Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland.
Hematology/Oncology Clinics of North America
|April 1, 1992
Abstract:
The natural history of multiple myeloma and related human plasma cell tumors is compared to the process of plasmacytomagenesis in mice. Intriguing new findings are beginning to give a more complete picture of the evolution of these tumors. Mouse plasmacytomas consistently develop chromosomal translocations that dysregulate c-myc, but consistent oncogenic mutations have not yet been defined in multiple myeloma.