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Oral bioadhesive drug delivery systems
Marcos Luciano Bruschi1, Osvaldo de Freitas
1Departamento de Farmácia e Farmacologia, Universidade Estadual de Maringá, Maringá, PR, Brazil.
Drug Development and Industrial Pharmacy
|April 16, 2005
Summary
Oral mucosal drug delivery offers a safe and effective route, bypassing the first-pass effect. Bioadhesive systems enhance drug absorption by maintaining close contact with the oral mucosa.
Area of Science:
- Biomedical Engineering
- Pharmaceutics
- Drug Delivery Systems
Background:
- The oral mucosa presents a viable, safe, and well-accepted site for drug administration.
- Its properties include permeability, robustness, rapid healing, allergen tolerance, and rich vascularization.
- Oral mucosal delivery circumvents the hepatic first-pass effect and gastrointestinal presystemic elimination.
Purpose of the Study:
- To systematically review literature on oral mucosal drug delivery.
- To explore environmental factors, delivery strategies, evaluation methods, and polymer utilization in this field.
Main Methods:
- Systematic literature review of relevant citations.
- Analysis of factors influencing oral bioadhesive drug delivery efficacy.
Main Results:
- Oral mucosal drug delivery is feasible and effective due to favorable mucosal characteristics.
- Bioadhesive systems improve drug concentration and flux by ensuring intimate contact with the tissue.
- Efficacy is contingent upon the biological environment and the properties of polymers and drugs.
Conclusions:
- Oral mucosal drug delivery is a promising strategy with significant advantages.
- Understanding the interplay between the biological environment, polymers, and drugs is crucial for optimizing bioadhesive systems.
- Further research into oral bioadhesive drug delivery systems is warranted.