Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amiodarone-induced thyroid dysfunction.

Ian Louis Ross1, David Marshall, Andrzej Okreglicki

  • 1Division of Endocrinology, Groote Schuur Hospital and University of Cape Town. iross@uctgsh1.uct.ac.za

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
|April 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variable contribution of inquilines to prey digestion in Nepenthes pitcher plants: the role of pitcher traits.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

Artificial intelligence in medical education: promise, caution, and the need for restraint.

Academic medicine : journal of the Association of American Medical Colleges·2026
Same author

Clinical utility of the Pediatric Bowel Management Scoring Tool in guiding management of childhood constipation-a prospective, multicenter study.

European journal of pediatrics·2026
Same author

A Rare Encounter: Mammary-Like Gland Tissue in an Anal Polyp.

Cureus·2026
Same author

Adrenal adenomata displaying mild autonomous cortisol secretion: a service evaluation of cardiometabolic profile routinely screened patients.

Cardiovascular endocrinology & metabolism·2026
Same author

Can artificial intelligence help with the development of generic clinical skills when breaking bad news? A quantitative evaluation.

Clinical medicine (London, England)·2026
Same journal

SAMA Health Summit Abstracts.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same journal

Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
See all related articles

Amiodarone therapy is linked to a high incidence of thyroid dysfunction (TD) in South Africa, with over 27% of patients developing new TD. Further research into local factors is needed.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Thyroid dysfunction (TD) frequency associated with amiodarone therapy in southern Africa is largely unknown.
  • Amiodarone is an effective antiarrhythmic drug but carries a risk of thyroid dysfunction.
  • Southern Africa is considered an iodine-replete area, potentially influencing TD rates.

Purpose of the Study:

  • To determine the incidence of new-onset thyroid dysfunction in patients receiving amiodarone.
  • To assess TD rates in a South African cohort at a cardiac clinic.
  • To compare TD incidence in an iodine-replete region with international data.

Main Methods:

  • Retrospective cohort study using pharmacy records from November 1999 to December 2002.
  • Identified 194 patients receiving amiodarone, with 163 included in the final analysis.

Related Experiment Videos

  • Collected data on patient demographics, indications for amiodarone, duration of therapy, and thyroid function outcomes.

    • Main Results:

    • A high incidence of new TD (27.6%) was observed in 163 patients.
    • Thyrotoxicosis (11 patients, 6.7%) and hypothyroidism (12 patients, 7.4%) were the most common forms of TD.
    • The median duration of amiodarone therapy until new TD diagnosis was significantly longer (943 days) compared to euthyroid patients (547 days).

    Conclusions:

    • The incidence of amiodarone-induced thyroid dysfunction in this South African cohort is high, comparable to international rates.
    • Local factors, potentially including iodine intake, may contribute to the observed TD rates and warrant further investigation.
    • These findings highlight the importance of monitoring thyroid function in patients on amiodarone therapy in this region.