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Updated: Aug 8, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 24, 2014
[Biological and evolutive spectrum of patients ANCA present]
A Covic1, Camelia Mutică, Anamaria Ignat
1Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Facultatea de Medicină, Clinica a IV-a Medicală-Nefrologie.
Aim:
To analyse the immuno-biological profile of patients with antineutrophil cytoplasmic antibodies (ANCA) presents. This is a retrospective study of all ANCA positives cases from Nephrology Clinic Iasi during five years (1998-2003) on a cohort of 97 patients.
Results:
pANCA was positive in 28, cANCA was positive in 60 and the others had pANCA and cANCA. The diseases ANCA associated were: systemic vasculitis, rapidly progressive glomerulonephritis (GNRP), chronic renal failure of an unknown etiology. ANCA presence was associated with inflammatory syndrome in 83.5%, anemic syndrome in 71.1%. From the patients with renal disfunction (71.1%), half of them presented an increased level of creatinine (>6 mg%). Renal biopsy proven especially crescentic glomerulonephritis. The complications and the diseases were more frequent in cANCA cases.
Conclusions:
cANCA presence is a negative prognosis factor in vasculitis; testing ANCA alone cannot be used to guide treatment.
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