Related Experiment Video
Updated: Aug 18, 2026

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
Clinical inquiries. What interventions can help patients stop using chewing tobacco?
Kenesha D Smith1, Mollie Ashe Scott, Elizabeth Ketterman
1Mountain Area Health Education Center, Asheville, NC, USA.
Abstract:
Nicotine replacement therapy (NRT), including gum and patches, decreases cravings and short-term abstinence rates, but does not improve long-term abstinence (strength of recommendation [SOR]: B, meta-analysis of small randomized controlled studies [RCT]). It is unclear if bupropion has an effect on cessation rates (SOR: B, small RCTs with conflicting results). Behavioral interventions increase abstinence rates for smokeless tobacco users (SOR: B, meta-analysis of small RCTs).
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