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Related Experiment Videos

Eosinophilic gastroenteritis.

Seema Khan1

  • 1Division of Gastroenterology, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA. seema.khan@chp.edu

Best Practice & Research. Clinical Gastroenterology
|April 19, 2005
PubMed
Summary
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Eosinophilic gastroenteritis (EG) is a primary eosinophilic gastrointestinal disorder often presenting with abdominal pain. Diagnosis requires tissue eosinophilia, and treatment involves diets, corticosteroids, and other agents, though questions remain about long-term management.

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic gastroenteritis (EG) is a primary eosinophilic gastrointestinal disorder, frequently presenting with abdominal pain.
  • Clinical presentation varies based on eosinophilic infiltration site and depth; atopy/allergies are common.
  • Secondary EG can occur with inflammatory bowel disease, autoimmune conditions, medications, infections, and post-transplantation.

Purpose of the Study:

  • To review the current understanding of eosinophilic gastroenteritis (EG) pathogenesis, diagnosis, and treatment.
  • To highlight the role of allergens, eosinophils, Th-2 cytokines, and eotaxin in EG.
  • To identify remaining questions regarding EG's natural history and long-term management.

Main Methods:

  • Literature review of recent investigations into EG pathogenesis.

Related Experiment Videos

  • Analysis of diagnostic criteria, emphasizing histopathological confirmation of tissue eosinophilia.
  • Evaluation of current treatment recommendations, including dietary restrictions, corticosteroids, and other agents.

    • Main Results:

    • Eosinophilic inflammation is mediated by allergens, eosinophils, Th-2 cytokines, and eotaxin.
    • Diagnosis is confirmed by identifying significant tissue eosinophilia via histopathology.
    • Treatment options include restricted diets, corticosteroids, leukotriene receptor antagonists, and mast cell stabilizers.

    Conclusions:

    • While progress has been made, significant questions persist regarding EG's natural history and optimal long-term treatment.
    • Further research is needed for safer, steroid-sparing therapies and reliable non-invasive follow-up methods.
    • Understanding the complex interplay of factors in EG is crucial for improving patient outcomes.