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The human obesity gene map: the 2004 update.

Louis Pérusse1, Tuomo Rankinen, Aamir Zuberi

  • 1Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte-Foy, Québec, Canada.

Obesity Research
|April 19, 2005
PubMed
Summary

The eleventh update of the human obesity gene map reviews over 600 genes and regions linked to obesity. This comprehensive map details single-gene mutations, Mendelian disorders, animal models, and human quantitative trait loci (QTLs).

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Area of Science:

  • Genetics
  • Obesity Research
  • Genomics

Background:

  • Obesity is a complex multifactorial condition with a significant genetic component.
  • Understanding the genetic basis of obesity is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To present the eleventh update of the human obesity gene map, synthesizing evidence from various genetic studies.
  • To catalog genes, loci, and quantitative trait loci (QTLs) associated with human obesity phenotypes.

Main Methods:

  • Review of published literature up to October 2004.
  • Inclusion of data from single-gene mutation cases, Mendelian disorders, animal models (transgenic, knockout, QTLs), association studies, and genome scans.
  • Compilation of genetic loci and candidate genes implicated in obesity.

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Main Results:

  • As of October 2004, 173 human obesity cases from 10 genes, 49 mapped loci for Mendelian syndromes, and 166 mouse obesity-related genes were reported.
  • 221 QTLs from animal models and 204 human obesity QTLs from 50 genome scans were identified, with 38 replicated regions.
  • 358 positive associations between 113 candidate genes and obesity phenotypes were found, with 18 genes supported by multiple studies.

Conclusions:

  • The human obesity gene map now includes over 600 genes, markers, and chromosomal regions linked to obesity.
  • The map demonstrates the widespread genetic influence on obesity across all chromosomes except Y.
  • An electronic version of the map is available for further research and exploration.