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Updated: Aug 18, 2026
Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Effect of inversion time on delayed-enhancement magnetic resonance imaging with and without phase-sensitive
Randolph M Setser1, Yiu Cho Chung, Joan A Weaver
1Section of Cardiovascular Imaging, Division of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. setserr@ccf.org
Purpose:
To evaluate the consistency and inversion time (TI) independence of phase-sensitive reconstruction (PSIR) delayed-enhancement (DE) MRI in a clinical setting.
Materials And Methods:
Mid-ventricular short-axis DE images were acquired in 25 patients using three TIs: 1) optimized to null viable myocardium, 2) 50 msec less than optimal TI, and 3) 50 msec greater than optimal TI. At each TI, images were acquired with PSIR and without magIR. In each image, percent scar was computed as the ratio of nonviable to total pixels in the left ventricle (LV).
Results:
In the magIR images, percent scar was 23% +/- 15% (optimal), 11% +/- 11% (short), and 22% +/- 15% (long). In PSIR images, percent scar was 25% +/- 15% (optimal), 22% +/- 15% (short), and 22% +/- 14% (long). Percent scar was significantly underestimated in magIR images with short TI, but no statistically significant difference in percent scar was observed at the optimal or long TIs.
Conclusion:
DE-MRI is a robust imaging technique for clinical use. PSIR provided consistent image quality independently of TI, at least over the range of TIs evaluated in this study. However, neither image quality nor scar appearance in the PSIR images was significantly different from that in the magIR images when TI was at or above the null point of viable myocardium.
Insights
Phase-sensitive reconstruction (PSIR) delayed-enhancement (DE) MRI offers consistent image quality independent of inversion time (TI). This technique ensures reliable scar assessment in clinical settings, outperforming traditional magIR methods with shorter TI.
Area of Science:
- Cardiovascular Imaging
- Magnetic Resonance Imaging
Background:
- Delayed-enhancement MRI (DE-MRI) is crucial for assessing myocardial scar.
- Optimizing inversion time (TI) is critical for accurate scar quantification.
Purpose of the Study:
- To evaluate the consistency and inversion time (TI) independence of phase-sensitive reconstruction (PSIR) delayed-enhancement (DE) MRI.
- To compare PSIR with traditional magIR techniques in a clinical setting.
Main Methods:
- DE-MRI images were acquired in 25 patients using three TIs: optimal, 50 msec less, and 50 msec greater than optimal.
- Images were reconstructed using both PSIR and magIR techniques.
- Percent scar was calculated as the ratio of nonviable to total left ventricular (LV) pixels.
Main Results:
- PSIR demonstrated consistent scar quantification across all evaluated TIs.
- MagIR images showed significant underestimation of scar at a TI 50 msec shorter than optimal.
- No significant difference in scar quantification was observed between PSIR and magIR at optimal or longer TIs.
Conclusions:
- PSIR-DE-MRI provides robust and TI-independent scar assessment in clinical practice.
- PSIR ensures consistent image quality, making it a reliable tool for myocardial scar evaluation.
- PSIR performance was comparable to magIR when TI was at or above the null point of viable myocardium.
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