Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cluster headache without autonomic symptoms: why is it different?

Isabel P Martins1, Raquel G Gouveia, Elsa Parreira

  • 1Centro de Estudos Egas Moniz, Instituto de Medicina Molecular, Lisbon Faculty of Medicine, Hospital de Santa Maria, Lisboa, Portugal.

Headache
|April 20, 2005
PubMed
Summary

Cluster headache (CH) without cranial autonomic symptoms (CAS) is linked to less intense pain. This suggests CH without CAS may be a milder form of the condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is achieving higher standards in real-world migraine care feasible with anti-CGRP monoclonal antibodies preventive therapies?: Insights from the EUREkA cohort.

Cephalalgia : an international journal of headache·2026
Same author

Long-Term Effectiveness and Persistence Factors of Anti-CGRP Monoclonal Antibodies in Migraine: 2-Year Results From the EUREkA Cohort.

Neurology·2026
Same author

Long-Term Effectiveness and Persistence Factors of Anti-CGRP Monoclonal Antibodies in Migraine: 2-Year Results From the EUREkA Cohort.

Neurology·2026
Same author

Headache phenotypes in insomnia, obstructive sleep apnea, and COMISA: Impact on diagnosis and therapy.

Dental and medical problems·2025
Same author

[Headache Management in Portugal: Consensus among the Portuguese Headache and Neurology Societies, the Portuguese Association of General and Family Medicine, and MiGRA].

Acta medica portuguesa·2025
Same author

Characterization of persistent headache attributed to past stroke.

Arquivos de neuro-psiquiatria·2022

Area of Science:

  • Neurology
  • Headache Medicine
  • Clinical Neuroscience

Background:

  • Cluster headache (CH) is a primary headache disorder characterized by severe unilateral pain and associated cranial autonomic symptoms (CAS).
  • A subset of CH patients presents with persistent attacks lacking CAS, a presentation whose underlying factors remain unclear.

Purpose of the Study:

  • To investigate and identify factors associated with the absence of cranial autonomic symptoms (CAS) in patients diagnosed with cluster headache (CH).
  • To determine if CH without CAS represents a distinct clinical subtype or a variant of typical CH.

Main Methods:

  • A prospective study involving 157 patients diagnosed with cluster headache (CH).
  • Comparison between 148 patients with typical CH (including CAS) and 9 patients with CH lacking CAS.

Related Experiment Videos

  • Analysis included demographic data, clinical characteristics, and attack parameters.

    • Main Results:

    • Patients experiencing CH without CAS reported significantly less intense pain compared to those with CAS (P = .003).
    • A non-significant trend suggested a higher prevalence of females and chronic CH in the group without CAS.
    • Logistic regression indicated that pain intensity was the primary differentiating factor between the two groups.

    Conclusions:

    • The findings support the hypothesis that cluster headache (CH) without cranial autonomic symptoms (CAS) represents a milder clinical manifestation of CH.
    • Reduced pain intensity is a key characteristic distinguishing CH without CAS from typical CH.