The metabolic syndrome
Robert H Eckel1, Scott M Grundy, Paul Z Zimmet
1Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA. Robert.Eckel@UCHSC.edu
Lancet (London, England)
|April 20, 2005
Summary
Metabolic syndrome, linked to obesity, involves insulin resistance and inflammation. Lifestyle changes like weight reduction are key, with medication for high-risk individuals to prevent type 2 diabetes and cardiovascular disease.
Area of Science:
- Metabolic Disorders
- Obesity Research
- Cardiovascular Health
Background:
- Metabolic syndrome is a prevalent disorder increasingly linked to rising obesity rates.
- Current definitions vary, but a unified global definition is anticipated.
- Key pathophysiological factors include insulin resistance and excessive fatty acid flux, alongside a proinflammatory state.
Purpose of the Study:
- To highlight the growing concern surrounding metabolic syndrome.
- To discuss the underlying pathophysiology including insulin resistance and inflammation.
- To emphasize the need for therapeutic attention due to increased risks of type 2 diabetes and cardiovascular disease.
Main Methods:
- Review of current understanding of metabolic syndrome pathophysiology.
- Analysis of the link between obesity, insulin resistance, and inflammation.
- Evaluation of risk factors for type 2 diabetes and cardiovascular disease.
Main Results:
- Metabolic syndrome is strongly associated with obesity.
- Insulin resistance and a proinflammatory state are central to its development.
- Individuals with metabolic syndrome face elevated risks for type 2 diabetes and cardiovascular disease.
Conclusions:
- Effective management of metabolic syndrome is crucial.
- Weight reduction and increased physical activity are primary interventions.
- Pharmacological interventions may be necessary for managing associated risks such as type 2 diabetes and cardiovascular disease.
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