Related Experiment Video
Updated: Aug 18, 2026

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
Published on: December 10, 2020
[Central hemodynamic changes in children reoperated on for congenital spinal cord hernia using balanced anesthesia
Insights
Balanced anesthesia using propofol and midazolam for spinal hernia reoperation showed no adverse hemodynamic effects. Flumazenil administration facilitated rapid recovery and tracheal extubation in both propofol and midazolam groups.
Area of Science:
- Anesthesiology
- Neurosurgery
- Cardiovascular Physiology
Context:
- Congenital spinal cord hernias often require complex surgical repair.
- Reoperation for spinal hernias presents unique anesthetic challenges.
- Maintaining hemodynamic stability is crucial during neurosurgical procedures.
Purpose:
- To evaluate the hemodynamic effects of balanced anesthesia using propofol and midazolam in patients undergoing reoperation for congenital spinal cord hernia.
- To assess the impact of flumazenil on recovery time and tracheal extubation.
Summary:
- Central hemodynamics were analyzed in 51 patients reoperated for congenital spinal cord hernia under balanced anesthesia (propofol and midazolam).
- The anesthetic protocol, involving bolus propofol with midazolam, demonstrated no negative hemodynamic effects.
- Intravenous flumazenil administration resulted in comparable, rapid recovery and tracheal extubation intervals between the propofol and midazolam groups.
Impact:
- This study supports the safety and efficacy of propofol-midazolam balanced anesthesia for spinal hernia reoperations.
- The findings suggest that flumazenil is an effective reversal agent, enabling predictable patient recovery.
- Optimized anesthetic management can improve patient outcomes in complex spinal neurosurgery.
Abstract:
The central hemodynamics was studied and analyzed in 51 patients reoperated on for congenital spinal cord hernia under balanced anesthesia based on midasolam and proforol. The procedure for anesthesiological provision of replastic repair of operated spinal hernia, which is based on propofol of bolus administration of midasolam with a hypnotic appliance, was found to cause no negative hemodynamic effects. When the benzodiazepine antagonist flumazenyl is used, the interval between the end of surgery and tracheal extubation is virtually identical in the propofol and midasolam groups since the intravenous injection of flumazenyl induces a drastic awakening effect.
Related Concept Videos
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Parenteral Anesthetics: Overview
Cardiomyopathy VII: Pre and Post Operative Nursing Management

