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Updated: Aug 18, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
[Effect of ABO-incompatibility on allogeneic hematopoietic stem cell transplantation]
Li Bao1, Xiao-jun Huang, Kai-yan Liu
1Institute of Hematology, Peking University People's Hospital, Beijing 100044, China.
Objective:
To explore the effect of ABO mismatch on clinical characteristics in allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Methods:
We retrospectively reviewed the clinical courses of 148 recipients of allo-HSCT from ABO-incompatible donors, of whom 85 ABO-compatible recipients were used as control group.
Results:
In ABO major incompatible group, the time of erythrocyte recovery after bone marrow transplantation (BMT) was delayed and more RBC transfusions were required as compared with ABO major incompatible peripheral blood stem cell transplantation (PBSCT). The incidence of acute graft versus host disease (aGVHD), cytomegalovirus (CMV) infection and survival had no significant difference between ABO-incompatible and ABO-compatible recipients for BMT, PBSCT and BMT+PBSCT.
Conclusion:
ABO-incompatibility has no adverse effect on the outcome of HSCT. Allogeneic PBSCT can reduce red blood cell transfusion requirements and facilitate erythrocyte recovery as compared with BMT.
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