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Cost-effectiveness of iodixanol in patients at high risk of contrast-induced nephropathy

Peter Aspelin1, Pierre Aubry, Sven-Göran Fransson

  • 1Department of Radiology, Karolinska University Hospital, Huddinge, Sweden. peter.aspelin@cfss.ki.se

American Heart Journal
|April 23, 2005
PubMed

Insights

Iodixanol, an isosmolar contrast medium, is more cost-effective than iohexol for patients undergoing angiography. This is due to fewer adverse events, including acute renal failure, leading to lower treatment costs.

Area of Science:

  • Nephrology
  • Radiology
  • Health Economics

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication of iodine-based contrast media.
  • CIN leads to acute renal failure, posing clinical and economic burdens.
  • Investigating cost-effectiveness of different contrast media for high-risk patients is crucial.

Purpose of the Study:

  • To compare the cost and cost-effectiveness of iodixanol versus iohexol in patients at high risk for CIN.
  • To evaluate the nephrotoxic effects and associated costs of two contrast media.

Main Methods:

  • A randomized, prospective, multinational clinical study compared iodixanol and iohexol.
  • Resource utilization data were collected from the study and patient records.
  • Swedish, German, and French unit prices were used for cost analysis.

Main Results:

  • Fewer serious adverse reactions, including acute renal failure, occurred with iodixanol compared to iohexol.
  • Mean hospitalization costs were lower with iodixanol across all analyzed unit prices.
  • Treatment costs for adverse drug reactions were significantly lower for iodixanol (P < 0.01).

Conclusions:

  • Isosmolar iodixanol is cost-effective compared to low-osmolar iohexol for diabetic patients with renal impairment undergoing angiography.
  • Iodixanol demonstrated both lower costs and better clinical outcomes (fewer adverse events).
  • This suggests iodixanol as a preferred agent for high-risk patients to mitigate CIN complications and costs.
Abstract

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