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Against the tide: Kurt Karl Stephan Semm (1927-2003)

Leon Morgenstern1

  • 1Center for Health Care Ethics, Cedars-Sinai Medical Center and the UCLA School of Medicine (Emeritus). morgenstern@cshs.org.

Surgical Innovation
|April 23, 2005
PubMed
Abstract

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...