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Treatment for methaqualone dependence in adults
G McCarthy1, B Myers, N Siegfried
1S.A. Cochrane Centre and Alcohol and Drug Research Group, Medical Research Council,, P.O. Box 19070, Tygerberg, Cape Town, W. Cape, South Africa, 7505. greg.mccarthy@mrc.ac.za
The Cochrane Database of Systematic Reviews
|April 23, 2005
Summary
No studies evaluated methaqualone (Quaalude, Mandrax) treatments. Evidence is lacking on effective interventions for this sedative-hypnotic drug
Area of Science:
- Pharmacology
- Psychiatry
- Public Health
Background:
- Methaqualone is a highly abusable sedative-hypnotic drug.
- Smoking methaqualone is a significant public health issue in South Africa, Africa, and India.
- Effective treatment strategies are needed due to diminishing resources for substance abuse.
Purpose of the Study:
- To review evidence on pharmacological or behavioral treatments for methaqualone dependence.
- To compare inpatient vs. outpatient settings, placebo vs. treatment, and different treatment modalities.
Main Methods:
- Searched Cochrane, MEDLINE, and PsycInfo databases up to February 2004.
- Included randomized controlled trials (RCTs) and quasi-RCTs.
- Independent assessment of study eligibility and quality.
Main Results:
- No studies met the inclusion criteria for the review.
- No randomized controlled trials were identified.
Conclusions:
- The effectiveness of any treatment for methaqualone abuse or dependence remains unestablished.
- Further research, particularly RCTs, is needed to guide treatment decisions.