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Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
Stoichiometric constraints and complete closure of long-term life support systems
1Institute of Biophysics, Siberian Branch of Russian Academy of Sciences, Krasnoyarsk, Russia. bartsev@online.ru
Abstract:
High closure of matter recycling is an obvious requirement for long-term life support systems (LSS). Biological species are obligate components of the LSS since physical/chemical components are not able yet to provide food for crew. However including biological species into LSS is difficult due to specific stoichiometric configuration of their inputs and outputs. Formally the problem is to estimate the ability for given set of species to provide complete closure of LSS. Two possible models of metabolism organization can be considered: rigid and flexible ones. Stoichiometric analyses showed that the rigid metabolism case is not typical and takes place with very specific requirements. The flexible metabolic model can be applied to describing wide range of systems. Some formal indications of ability to provide complete closure and stationarity of LSS state are considered in the paper. These indications establish some constraints on the form of mathematical models intended to describe artificial and natural ecological systems.
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