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Updated: Aug 18, 2026

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Published on: June 30, 2022
AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7
Salah E Abdel-Ghany1, Jason L Burkhead, Kathryn A Gogolin
1Department of Biology, Colorado State University, Anatomy/Zoology Building, Fort Collins, 80523, USA.
Abstract:
In plant chloroplasts two superoxide dismutase (SOD) activities occur, FeSOD and Cu/ZnSOD, with reciprocal regulation in response to copper availability. This system presents a unique model to study the regulation of metal-cofactor delivery to an organelle. The Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD. The AtCCS protein was localized to chloroplasts where it may supply copper to the stromal Cu/ZnSOD. AtCCS mRNA expression levels are upregulated in response to Cu-feeding and senescence. We propose that AtCCS expression is regulated to allow the most optimal use of Cu for photosynthesis.
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