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Updated: Aug 18, 2026

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
[Antioxidative properties of human milk]
Agnieszka Szalagatys-Sidorkiewicz1, Maciej Zagierski, Joanna Renke
1Klinika Pediatrii, Gastroenterologii i Onkologii, Dziecieca Akademia Medyczna, 80-803 Gdańsk, Poland. agal@amg.gda.pl
Insights
Human milk provides essential antioxidants, reducing oxidative stress in breastfed infants. Factors like maternal diet and smoking influence milk
Area of Science:
- Neonatal nutrition and oxidative stress research.
- Human milk composition and infant health.
Context:
- Oxidative stress is a significant risk factor for serious infant conditions like bronchopulmonary dysplasia, retinopathy of prematurity, and necrotizing enterocolitis.
- Understanding the role of human milk in mitigating oxidative stress is crucial for neonatal care.
Purpose:
- To investigate the impact of human milk on oxidative stress levels in neonates and infants.
- To explore factors affecting the antioxidant properties of human milk.
Summary:
- Human milk possesses inherent antioxidative properties that protect breastfed infants from oxidative stress.
- Breastfed infants exhibit higher blood antioxidant capacity and lower oxidative stress compared to formula-fed infants.
- Antioxidant levels in human milk are influenced by maternal diet, supplementation, geography, and storage, while maternal smoking negatively impacts these levels.
Impact:
- Highlights the protective role of human milk against oxidative stress-related infant diseases.
- Informs nutritional guidelines for mothers to optimize the antioxidant content of breast milk.
- Emphasizes the importance of breastfeeding for infant health and disease prevention.
Abstract:
Human milk, despite numerous advantages, has also antioxidative properties. Oxidative stress is implicated in bronchopulmonary dysplasia, retinopathy of prematurity and necrotizing enterocolitis. Therefore, the influence of human milk on oxidative stress intensity in breast-fed neonates and infants is a significant issue. The concentration of antioxidants in milk depends on mother's diet, vitamins supplementation during pregnancy and lactation and geographical area of domicile. Breast-fed children have higher antioxidative capacity in blood and lower oxidative stress intensity as compared to formula-fed children. Storage increases the antioxidative activity of human milk. Maternal smoking augments oxidative damage in children and lowers the antioxidative capacity of milk.
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