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Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia
H G Bernstein1, H Kirschke, B Wiederanders
1Institute of Neurobiology and Brain Research Magdeburg, Martin-Luther-University Halle, Wittenberg, Germany.
Acta Histochemica. Supplementband
|January 1, 1992
Abstract:
The cathepsin B, D and L were studied by immunohistochemical techniques in the human postmortem brain. The enzyme were primarily localized in neurons. Makroglial cells were seldom immunostained. It is shown that cathepsins B and D frequently occur in neuritic plaques of Alzheimer victims, thereby raising the question, whether or not cathepsin immunohistochemistry is a useful tool in the diagnosis of this disease. Furthermore, we identified certain glial cells to be immunoreactive for cathepsins in schizophrenics.