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Related Experiment Videos

Serpiginous choroiditis.

Wee-Kiak Lim1, Ronald R Buggage, Robert B Nussenblatt

  • 1National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA; and Singapore National Eye Centre, Singapore.

Survey of Ophthalmology
|April 27, 2005
PubMed
Summary
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Serpiginous choroiditis is a rare, progressive eye inflammation causing vision loss. Current treatments show limited efficacy, necessitating further research into its causes and effective management strategies.

Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Serpiginous choroiditis is a rare, chronic, and progressive inflammatory eye disease.
  • It affects the choroid, retinal pigment epithelium, and choriocapillaris, often leading to significant vision loss.

Purpose of the Study:

  • To review the clinical presentation, pathology, and current understanding of serpiginous choroiditis.
  • To highlight the need for further research into its etiology and treatment.

Main Methods:

  • Review of clinical and histological findings.
  • Discussion of diagnostic tools like fluorescein and indocyanine green angiography.
  • Analysis of current treatment approaches and their limitations.

Main Results:

  • Serpiginous choroiditis presents in peripapillary, macular, and ampiginous types, all with progressive courses.

Related Experiment Videos

  • Visual outcomes depend on foveal involvement and secondary choroidal neovascularization.
  • Histology shows choriocapillaris atrophy, RPE and photoreceptor damage, and lymphocytic infiltration.

    • Conclusions:

    • The etiology of serpiginous choroiditis remains unknown despite proposed theories.
    • Long-term follow-up is crucial for assessing treatment efficacy.
    • Immunosuppressive and alkylating agents show potential but require validation through larger clinical studies and trials.