Related Experiment Video
Updated: Jul 6, 2026

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
Published on: January 19, 2019
DNA hydrolyzing autoantibodies
A M Shuster1, G V Gololobov, O A Kvashuk
1V.A. Engelhardt Institute of Molecular Biology, Academy of Sciences of Russia, Moscow.
Abstract:
A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.
Related Concept Videos
The DNA Helix
DNA Isolation
Overview of DNA Repair
Chemically...
DNA Isolation
Single-Strand DNA Binding Proteins
Overview of DNA Repair
Chemically...

