Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The P2 receptors in platelet function.

Béatrice Hechler1, Marco Cattaneo, Christian Gachet

  • 1INSERM, Etablissement Français du Sang-Alsace, 10 Rue Spielmann, BP 36-67065 Strasbourg Cedex, France.

Seminars in Thrombosis and Hemostasis
|April 27, 2005
PubMed
Summary

Platelets release nucleotides that activate P2 receptors, amplifying platelet responses. Targeting these P2 receptors offers potential for developing new antithrombotic drugs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The p.T216R mutation of the thromboxane A2 receptor disrupts platelet function by selectively altering the G12/13 signaling pathway.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Pathogen-reduced plasma, cryoprecipitate reduced for therapeutic plasma exchange.

Transfusion·2026
Same author

Aspirin is a life-saving drug for patients with acute myocardial infarction.

Haematologica·2024
Same author

Nanoporous Submicron Gold Particles Enable Nanoparticle-Based Localization Optoacoustic Tomography (nanoLOT).

Small (Weinheim an der Bergstrasse, Germany)·2024
Same author

Estimating Molecular Thermal Averages with the Quantum Equation of Motion and Informationally Complete Measurements.

Entropy (Basel, Switzerland)·2024
Same author

From conservative to interventional management in unruptured intracranial aneurysms.

Journal of neurosurgery·2024

Area of Science:

  • Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Platelet activation is crucial after vessel injury, involving mediators like thromboxane A(2) (TXA(2)) and nucleotides.
  • Released nucleotides amplify platelet responses through a positive feedback mechanism.
  • Adenine nucleotides mediate these effects via three distinct P2 receptors: P2Y(1), P2Y(12), and P2X(1).

Purpose of the Study:

  • To elucidate the roles of distinct P2 receptor subtypes in platelet function.
  • To understand the signaling pathways coupled to these receptors.
  • To identify P2 receptors as potential targets for antithrombotic therapies.

Main Methods:

  • The study focuses on the functional roles of P2Y(1), P2Y(12), and P2X(1) receptors in platelet activation.
  • Analysis of signal transduction pathways activated by adenosine diphosphate (ADP) and adenosine triphosphate (ATP).
  • Investigation of receptor involvement in platelet aggregation, shape change, and response to various agonists.

Main Results:

  • P2Y(1) receptor initiates platelet aggregation, while P2Y(12) is essential for its completion and potentiates responses to other agonists.
  • P2Y(12) is the target of clopidogrel, highlighting its antithrombotic significance.
  • P2X(1) receptor contributes to platelet shape change and collagen-induced activation under shear stress.

Conclusions:

  • Distinct P2 receptors (P2Y(1), P2Y(12), P2X(1)) play differential roles in sequential platelet activation events.
  • Understanding these P2 receptor functions is key to developing targeted antithrombotic strategies.
  • P2 receptors represent promising molecular targets for novel antithrombotic drug development.

Related Experiment Videos