Risperidone-Induced Nasal Congestion and Increased Urinary Frequency

Risperidone is a second-generation antipsychotic that is widely used in the treatment of psychotic disorders. It is generally well tolerated, although uncommon adverse effects have been reported. Nasal congestion and urinary frequency have only rarely been described in association with risperidone treatment. A 27-year-old male with delusional disorder developed nasal congestion and urinary frequency after starting risperidone. He underwent evaluation by both family medicine and otolaryngology (ENT), and no alternative cause of his symptoms was identified. Despite treatment with antihistamines, intranasal budesonide, and xylometazoline, his symptoms persisted. The symptoms resolved when he stopped taking risperidone for two days and returned when the medication was restarted. Risperidone was subsequently discontinued and replaced with aripiprazole. Following the switch, the patient's symptoms resolved completely. This case suggests a probable association between risperidone and the development of nasal congestion and urinary frequency. Awareness of these uncommon adverse effects may help clinicians identify medication-related symptoms, avoid unnecessary investigations, and improve treatment adherence.