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Biomimetic synthesis of antimalarial naphthoquinones
Jeremiah P Malerich1, Thomas J Maimone, Gregory I Elliott
1Department of Chemistry, University of California-Berkeley, Berkeley, California 94720-1460, USA.
Abstract:
The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described. Pinnatal, isopinnatal, sterekunthals A and B, pyranokunthones A and B, and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps. The first case of catalysis in oxa 6pi electrocyclizations is reported.
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