Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Closed circular DNA as a probe for protein-induced structural changes.

J H White1, R M Gallo, W R Bauer

  • 1Department of Mathematics, University of California, Los Angeles 90024.

Trends in Biochemical Sciences
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Magnetic resonance imaging and active cardiac implants].

Herzschrittmachertherapie & Elektrophysiologie·2019
Same author

The influence of spatial patterns of capillary networks on transverse relaxation.

Magnetic resonance imaging·2017
Same author

A quantitative evaluation of thermal pulp testing.

Journal of endodontics·2016
Same author

Vitamin D and its receptor during late development.

Biochimica et biophysica acta·2014
Same author

Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease.

Mucosal immunology·2014
Same author

Case series evidence for changed interhemispheric relationships in cortical structure in some amputees.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2013

Closed circular DNA, found in biological systems, has unique topological constraints. These constraints alter DNA structure and reactivity, enabling its use in studying DNA-protein interactions.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Structural Biology

Background:

  • DNA frequently exists in closed circular structures within biological systems, often interacting with proteins.
  • These circular DNA molecules possess inherent topological constraints.

Purpose of the Study:

  • To explore the impact of topological constraints on closed circular DNA.
  • To highlight the utility of closed circular DNA as an analytical tool for DNA-protein complexes.

Main Methods:

  • The study focuses on the theoretical and analytical implications of DNA topology.
  • No specific experimental methods are detailed, emphasizing conceptual understanding.

Main Results:

  • Topological constraints significantly influence the structure and reactivity of closed circular DNA.

Related Experiment Videos

  • These constraints are crucial for understanding DNA behavior in biological contexts.

    • Conclusions:

    • Closed circular DNA's unique topological properties are fundamental to its function and interaction with proteins.
    • The topological nature of DNA provides a basis for developing novel analytical methods for studying DNA-protein complexes.