Related Experiment Videos
Closed circular DNA as a probe for protein-induced structural changes
J H White1, R M Gallo, W R Bauer
1Department of Mathematics, University of California, Los Angeles 90024.
Trends in Biochemical Sciences
|January 1, 1992
Abstract:
Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes.