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Updated: Jul 29, 2026
13:18
Single Oocyte Bisulfite Mutagenesis
Published on: June 27, 2012
Genetic imprinting: conflict at the Callipyge locus
1Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK.
Current Biology : CB
|April 28, 2005
Abstract:
The imprinted Dlk1-Gtl2 region of the mammalian genome - which in sheep encompasses the Callipyge locus, known for its unusual mode of inheritance - encodes a number of maternally expressed miRNAs. Five of these miRNAs, hosted by the antisense transcript antiPeg11, have now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mechanism.
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