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Updated: Aug 18, 2026

Heterotopic and Orthotopic Tracheal Transplantation in Mice used as Models to Study the Development of Obliterative Airway Disease
Published on: January 20, 2010
Airway obstruction owing to tracheopathia osteoplastica: treatment by linear tracheoplasty
Hermes C Grillo1, Cameron D Wright
1Thoracic Surgical Division, the Surgical Services, Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA. pguerriero@partners.org
Background:
Tracheopathia osteoplastica is a rare disease that may involve the entire trachea and progress to critical airway obstruction. It is not dilatable and does not respond to laser therapy or bronchoscopic curettage. Stents usually cannot be inserted.
Methods:
Lack of involvement of the membranous wall by the disease allows tracheal widening after complete linear tracheoplasty. Opening is preserved during healing by prolonged stenting with a T or T-Y silicone tube.
Results:
Stent removal after firm healing produced long-term correction of stenosis in 3 of 4 patients, examined up to 12 years.
Conclusions:
Severe, symptomatic tracheal obstruction by tracheopathia osteoplastica is definitively surgically correctible.
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