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Is periodontitis associated with oral neoplasms?
Mine Tezal1, Sara G Grossi, Robert J Genco
1Department of Oral Biology, University at Buffalo, Buffalo, NY, USA. mtezal@buffalo.edu
Journal of Periodontology
|April 29, 2005
Summary
Periodontal disease, indicated by clinical attachment loss, is linked to a higher risk of oral tumors and precancerous lesions. Further research is needed to confirm the association between gum disease and oral cancer development.
Area of Science:
- Oral Health
- Oncology
- Periodontology
Background:
- Infections are implicated in oral cancer etiology.
- This study investigates the link between periodontal disease and oral soft tissue lesions.
Purpose of the Study:
- To evaluate the effect of periodontal disease on oral soft tissue lesions.
- To assess the association between clinical attachment loss and oral tumors or precancerous lesions.
Main Methods:
- Utilized data from 13,798 adults in the Third National Health and Nutrition Examination Survey (NHANES III).
- Periodontal disease severity measured by clinical attachment loss (CAL).
- Weighted multiple logistic regression analyses adjusted for numerous covariates.
Main Results:
- Clinical attachment loss (CAL) was not significantly associated with any soft tissue lesion (OR = 1.09).
- CAL showed a significant association with the presence of tumors (OR = 4.57) and precancerous lesions (OR = 1.55).
Conclusions:
- Suggests an association between periodontal disease and the risk of precancerous lesions and tumors.
- Generates a hypothesis for a potential relationship between periodontal disease and oral neoplasms.
- Recommends prospective studies for confirmation.