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Microalbuminuria in Hodgkin's disease
1Department of Hematology, Yüzüncü Yil University School of Medicine, 65200 Van, Turkey. imdilek@hotmail.com
International Journal of Clinical Practice
|April 29, 2005
Summary
Urinary albumin excretion (UAE) was elevated in Hodgkin
Area of Science:
- Nephrology
- Oncology
Background:
- Urinary albumin excretion (UAE) is linked to prognosis in certain cancers.
- Hodgkin's disease is a malignancy affecting the lymphatic system.
Purpose of the Study:
- To investigate 24-hour UAE in untreated Hodgkin's disease patients.
- To assess the relationship between UAE and disease stage.
Main Methods:
- Measured 24-hour UAE in 34 Hodgkin's disease patients and 19 healthy controls.
- Defined microalbuminuria (MAU) as UAE ≥ 20 µg/min.
- Re-evaluated UAE post-treatment in patients with MAU.
Main Results:
- Mean UAE was significantly higher in Hodgkin's disease patients (31.2 µg/min) versus controls (5.6 µg/min).
- Microalbuminuria (MAU) was present in 47% of patients, compared to 0% in controls.
- UAE and MAU showed a non-significant trend towards higher levels in advanced-stage disease.
Conclusions:
- Hodgkin's disease is associated with increased urinary albumin excretion.
- No significant correlation was found between UAE and the extent of Hodgkin's disease.