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Related Experiment Videos

Persistent serpentine supravenous hyperpigmented eruption associated with docetaxel.

I Aydogan1, A Kavak, A H Parlak

  • 1Department of Dermatology, Abant Izzet Baysal University, Duzce Medical School, 81620 Konuralp, Duzce, Turkey.

Journal of the European Academy of Dermatology and Venereology : JEADV
|April 29, 2005
PubMed
Summary

A rare skin reaction, persistent serpentine supravenous hyperpigmented eruption (PSSHE), can occur after docetaxel chemotherapy. Proper venous washing after docetaxel infusion may prevent this docetaxel-induced discoloration.

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Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Systemic docetaxel can cause various mucocutaneous reactions.
  • A persistent serpentine supravenous hyperpigmented eruption (PSSHE) is a rare adverse effect.
  • This reaction involves discoloration along the superficial venous network.

Purpose of the Study:

  • To report a case of docetaxel-induced PSSHE.
  • To discuss the terminology and potential mechanisms of this reaction.
  • To highlight the importance of proper venous washing after docetaxel administration.

Main Methods:

  • Case report of a 47-year-old male patient treated with docetaxel.
  • Observation of skin reaction after docetaxel infusion.
  • Comparison of reaction occurrence with and without adequate venous washing.

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Main Results:

  • The patient developed PSSHE after the first docetaxel infusion with insufficient venous washing.
  • A similar eruption did not occur after the second infusion when abundant venous washing was performed.
  • This is the second reported case of docetaxel-induced supravenous discoloration.

Conclusions:

  • Docetaxel can induce supravenous discoloration, a rare mucocutaneous reaction.
  • Adequate venous washing appears to be a crucial preventive measure.
  • Further investigation into the mechanism of docetaxel-induced PSSHE is warranted.