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14-3-3 proteins--an update

Paulette Mhawech1

  • 1Department of Pathology and Laboratory Medicine at Roswell Park Cancer Institute, Buffalo, New York 14263, USA. pmhawech1@yahoo.com

Cell Research
|April 29, 2005
PubMed

Insights

The 14-3-3 protein family regulates crucial cell functions. A specific isoform, 14-3-3sigma, is implicated in human cancers due to gene silencing, suggesting it as a potential therapeutic target.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The 14-3-3 protein family is highly conserved, with seven mammalian isoforms.
  • These proteins interact with over 200 targets, influencing cell cycle, growth, survival, and apoptosis.
  • While 14-3-3 functions are extensively studied, the consequences of their interactions are still under investigation.

Purpose of the Study:

  • To explore the role of 14-3-3 proteins, particularly 14-3-3sigma, in human cancer.
  • To understand the regulatory mechanisms of 14-3-3sigma, including its interaction with p53 and epigenetic deregulation.
  • To assess the potential of targeting 14-3-3sigma for cancer therapy.

Main Methods:

  • Literature review of recent studies on 14-3-3 protein functions and cancer relevance.
  • Analysis of regulatory mechanisms including p53-mediated regulation and epigenetic modifications like CpG methylation.
  • Examination of gene silencing of 14-3-3sigma in various human cancer types.

Main Results:

  • 14-3-3 proteins are critical regulators of diverse cellular processes.
  • 14-3-3sigma is specifically linked to human cancer development and progression.
  • Gene silencing of 14-3-3sigma via CpG methylation is observed in numerous cancers.

Conclusions:

  • 14-3-3sigma plays a significant role in human oncogenesis.
  • Epigenetic silencing of 14-3-3sigma is a key mechanism in cancer.
  • Targeting 14-3-3sigma presents a promising avenue for future cancer therapeutics.

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