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Related Experiment Videos

Primary antibody deficiency and diagnostic delay.

B Seymour1, J Miles, M Haeney

  • 1Department of Immunology, Clinical Sciences Building, Hope Hospital, Stott Lane, Salford M6 8HD, UK.

Journal of Clinical Pathology
|April 29, 2005
PubMed
Summary

Diagnostic delay in primary antibody deficiency persists, though moderate improvements are noted since 1989 and 1995 UK guidelines. This delay leads to significant patient morbidity from infections.

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Area of Science:

  • Clinical Immunology
  • Immunodeficiency Disorders

Background:

  • Primary antibody deficiency (PAD) diagnosis is often delayed.
  • Previous studies and national guidelines aimed to improve diagnostic timelines.

Purpose of the Study:

  • To evaluate diagnostic delay in PAD between 1989-2002.
  • To assess the impact of UK national guidelines introduced in 1995 on diagnostic delay.

Main Methods:

  • Retrospective case note review of 89 patients with antibody deficiency.
  • Assessment of diagnostic delay and associated infection-related morbidity.

Main Results:

  • 56 out of 89 patients experienced diagnostic delay, with a median delay of 2 years.
  • Delay resulted in significant morbidity, equivalent to two major and one minor infection.
  • Moderate improvement observed since 1989 and post-1995 guidelines.

Conclusions:

  • Considerable diagnostic delay in PAD remains.
  • Evidence suggests improved diagnostic practices following the 1989 study and 1995 guidelines.

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