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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
Published on: October 31, 2016
Transcriptional regulation of endothelin
J T Koo1, M D Sawyer, R J Powell
1Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
Abstract:
Three isoforms of endothelin (ET) exist, ET-l, ET-2,and ET-3.Nucleotide sequences for the three human ET genes are highly conserved. ET-l exactly matches the sequence ofET originally isolated from the condi- tioned medium of cultured bovine aortic endothelial cells (BAECs)."All three forms have been found in vascular, neural, adrenal, and kidney tissue, but are expressed in different proportions. Endothelial cells ex- clusively produce ETAll three isoforms have different vasoconstrictive potencies but are otherwise quali- tatively similar. ET-2 is the most potent vasoconstrictor, followed by ET-l and ET.
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