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Socio-economic characteristics in children with coeliac disease

J F Ludvigsson1,

  • 1Paediatric Department, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.com

Acta Paediatrica (Oslo, Norway : 1992)
|April 30, 2005
PubMed

Insights

Maternal employment for less than three months during pregnancy was linked to a reduced risk of coeliac disease in children. Most other socio-economic factors showed no significant association with coeliac disease development.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Epidemiology

Background:

  • Coeliac disease is an autoimmune disorder triggered by gluten.
  • Understanding the influence of socio-economic factors on coeliac disease is crucial for public health initiatives.
  • Previous research has explored various risk factors, but the role of socio-economic determinants requires further investigation.

Purpose of the Study:

  • To investigate the association between socio-economic factors and the incidence of coeliac disease in a pediatric cohort.
  • To identify potential socio-economic predictors that may influence the development of coeliac disease.

Main Methods:

  • Prospective cohort study (ABIS study) of 16,286 children born between 1997 and 1999.
  • Coeliac disease diagnosis confirmed via biopsy.
  • Logistic regression analysis of socio-economic characteristics, infant sex, parental factors, and maternal alcohol consumption.

Main Results:

  • A reduced risk of coeliac disease was observed in offspring whose mothers worked less than three months during pregnancy (OR = 0.29, p=0.039).
  • This association remained significant after adjusting for confounders (aOR = 0.28, p=0.035).
  • No other analyzed socio-economic factors demonstrated a significant relationship with coeliac disease incidence.

Conclusions:

  • Maternal employment duration during pregnancy appears to be a significant factor influencing coeliac disease risk.
  • Most other socio-economic factors investigated are likely of minimal importance in the development of coeliac disease.
  • Further research may explore the biological mechanisms underlying the observed association between short-term maternal employment and reduced coeliac disease risk.
Abstract

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