Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mesenchymal stem cells: future source for reparative medicine.

Rinky Bhatia1, Joshua M Hare

  • 1Department of Medicine, Division of Cardiology and Institute for Cell Engineering (ICE), Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Congestive Heart Failure (Greenwich, Conn.)
|April 30, 2005
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for treating heart failure by regenerating damaged heart muscle and blood vessels. Research explores MSCs for cardiomyogenesis and vasculogenesis in post-infarct hearts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LDLR-OPN Interaction Drives COVID-19 Myocarditis Through Monocyte Recruitment.

JACC. Basic to translational science·2026
Same author

Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty.

Cell stem cell·2026
Same author

Design and rationale of CATO, a Phase IIA, randomized, double-blind, placebo-controlled study of single or repeated intravenous administration of umbilical cord-derived mesenchymal stromal cells in ischemic cardiomyopathy.

American heart journal·2025
Same author

Phase I Randomized Study of Cardiac Stem Cells in Patients With Hypoplastic Left Heart Syndrome: The CHILD Trial.

JACC. Heart failure·2025
Same author

Targeting endoplasmic reticulum stress and nitroso-redox imbalance in neuroendocrine prostate cancer: the therapeutic role of nitric oxide.

Cell death discovery·2025
Same author

Cerebral vascular tortuosity and aneurysm formation and rupture: a novel vessel tortuosity scale.

Experimental neurology·2025

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Ischemic cardiomyopathy treatments focus on managing myocardial damage.
  • Generating new myocardium and vasculature offers a novel therapeutic approach for heart failure.
  • Stem cell research is pivotal for exploring new cardiac repair strategies.

Purpose of the Study:

  • To review the role of mesenchymal stem cells (MSCs) in promoting cardiomyogenesis and vasculogenesis in post-infarct myocardium.
  • To examine factors influencing MSC differentiation, delivery methods, and engraftment detection.

Main Methods:

  • Review of animal and human clinical trials involving MSC transplantation.
  • Analysis of studies on factors stimulating MSC differentiation.

Related Experiment Videos

  • Evaluation of MSC delivery routes and engraftment detection techniques.

    • Main Results:

    • MSCs exhibit multilineage potential, differentiating into myocardial and endothelial cells.
    • MSCs possess immunomodulatory properties, evading host immune detection.
    • Ease of MSC expansion in culture supports their therapeutic potential.

    Conclusions:

    • MSCs represent a promising stem cell source for cardiac repair in ischemic cardiomyopathy.
    • Further research is needed to optimize MSC-based therapies for heart failure treatment.