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Crohn's disease defined in three elderly sisters.

Hugh J Freeman1

  • 1Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver. hugfree@shaw.ca

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|April 30, 2005
PubMed
Summary

This study reports on three elderly sisters with late-onset Crohn's disease affecting the ileum and colon. Familial clustering suggests a potential genetic or environmental cause for this rare presentation.

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Area of Science:

  • Gastroenterology
  • Genetics
  • Epidemiology

Background:

  • Crohn's disease is a chronic inflammatory bowel disease.
  • Familial clustering of Crohn's disease suggests genetic and environmental influences.
  • Late-onset disease presentation is less common.

Observation:

  • Three elderly sisters presented with symptomatic Crohn's disease.
  • All sisters exhibited ileocolic involvement.
  • Granulomatous inflammation was confirmed histologically.

Findings:

  • This case series documents a rare instance of very late phenotypical expression of familial ileocolic Crohn's disease.
  • The observations highlight the potential for delayed disease onset in genetically predisposed individuals.
  • The familial occurrence suggests a shared genetic susceptibility or environmental trigger.

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Implications:

  • Understanding late-onset familial Crohn's disease can improve diagnostic approaches.
  • Further research into genetic and environmental factors is warranted.
  • This case contributes to the understanding of Crohn's disease heterogeneity.