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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

242
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
242
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

323
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
323
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

179
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

495
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
495
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

369
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Large Intestine01:09

Large Intestine

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The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
The ileocecal sphincter, a mucous membrane fold, guards the opening from the ileum to the large intestine. This valve permits material from the small intestine to pass into the large intestine. Attached to the ileocecal valve is the cecum. This small pouch, approximately 6 cm long, has a twisted, coiled tube known as...
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Updated: Jul 31, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Segmental Colitis Associated with Diverticulosis (SCAD).

Hugh J Freeman1,2

  • 1Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada. hugfree@shaw.ca.

Current Gastroenterology Reports
|May 2, 2023
PubMed
Summary
This summary is machine-generated.

Segmental colitis associated with diverticulosis (SCAD) is a benign, drug-responsive condition. Emerging evidence suggests potential links to certain medical treatments and infections, impacting its understanding.

Keywords:
Crohn’s DiseaseDiverticulitisDiverticulosisLong-term Follow-up and Natural HistorySCADSegmental Colitis

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Area of Science:

  • Gastroenterology
  • Colorectal Diseases
  • Inflammatory Bowel Disease

Background:

  • Segmental colitis associated with diverticulosis (SCAD) is a distinct colonic inflammatory process.
  • Historically recognized, primarily in elderly patients.

Purpose of the Study:

  • To review the distinctive features of SCAD.
  • To explore recent evidence on its natural history and pathogenesis.
  • To discuss clinical implications for diagnosis and treatment.

Main Methods:

  • Literature review of natural history studies.
  • Analysis of meta-analyses on SCAD.
  • Examination of case reports and clinical observations.

Main Results:

  • SCAD typically follows a benign clinical course.
  • The condition is generally responsive to drug therapy.
  • New associations with monoclonal antibody therapy and COVID-19 infection are noted.

Conclusions:

  • Recognition of SCAD is crucial for appropriate patient management.
  • Understanding SCAD's pathogenesis may be enhanced by its association with specific treatments and infections.
  • Clinical practice and trials require awareness of this colonic inflammatory pattern.