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Adenosine level in exhaled breath increases during exercise-induced bronchoconstriction.
1National Korányi Institute for Tuberculosis and Pulmonology, Dept of Pathophysiology, Budapest, Pihenö u.1. P.O. Box 1, H-1529, Hungary.
The European Respiratory Journal
|May 3, 2005
Summary
Exercise challenges increase adenosine levels in the airways of asthma patients, contributing to bronchoconstriction. This study measured adenosine in exhaled breath condensate (EBC) and lung function (FEV1) post-exercise.
Area of Science:
- Respiratory Medicine
- Pulmonary Physiology
- Biochemistry
Background:
- Exercise challenges can provoke airway obstruction in asthma patients.
- Elevated plasma adenosine levels are observed in asthmatic patients during exercise-induced bronchoconstriction.
Purpose of the Study:
- To investigate the association between exercise-induced bronchoconstriction and local adenosine concentration changes within the airways.
- To determine if adenosine levels in exhaled breath condensate (EBC) reflect airway changes during exercise in asthma.
Main Methods:
- Collected oral exhaled breath condensate (EBC) and measured forced expiratory volume in one second (FEV1) at rest and post-exercise in healthy and asthmatic subjects.
- Quantified adenosine concentration in EBC using High-Performance Liquid Chromatography (HPLC).
Main Results:
- Asthmatic patients exhibited significant bronchoconstriction (mean fall in FEV1 27%) and a marked increase in EBC adenosine levels (110%) after exercise, unlike healthy controls.
- A significant correlation was found between exercise-induced changes in adenosine concentration and the degree of FEV1 reduction in asthmatic patients.
Conclusions:
- Increased adenosine concentration in EBC likely reflects airway changes occurring during exercise-induced bronchoconstriction in asthma.
- Adenosine, due to its bronchoconstrictor properties, may play a role in the development of exercise-induced bronchospasm in asthma.